Sabtu, 07 Februari 2009

The Glutamine Synthetase Reaction



The Glutamine Synthetase Reaction

The glutamine synthetase reaction is also important in several respects. First it produces glutamine, one of the 20 major amino acids. Second, in animals, glutamine is the major amino acid found in the circulatory system. Its role there is to carry ammonia to and from various tissues but principally from peripheral tissues to the kidney, where the amide nitrogen is hydrolyzed by the enzyme glutaminase (reaction below); this process regenerates glutamate and free ammonium ion, which is excreted in the urine.

Note that, in this function, ammonia arising in peripheral tissue is carried in a non-ionizable form which has none of the neurotoxic or alkalosis-generating properties of free ammonia.
Liver contains both glutamine synthetase and glutaminase but the enzymes are localized in different cellular segments. This ensures that the liver is neither a net producer nor consumer of glutamine. The differences in cellular location of these two enzymes allows the liver to scavenge ammonia that has not been incorporated into urea. The enzymes of the urea cycle are located in the same cells as those that contain glutaminase. The result of the differential distribution of these two hepatic enzymes makes it possible to control ammonia incorporation into either urea or glutamine, the latter leads to excretion of ammonia by the kidney.
When acidosis occurs the body will divert more glutamine from the liver to the kidney. This allows for the conservation of bicarbonate ion since the incorporation of ammonia into urea requires bicarbonate (see below). When glutamine enters the kidney, glutaminase releases one mole of ammonia generating glutamate and then glutamate dehydrogenase releases another mole of ammonia generating α-KG. The ammonia will ionizes to ammonium ion (NH4+) which is excreted. The net effect is a reduction in the concentration of hydrogen ion, [H+], and thus an increase in the pH (see also Kidneys and Acid-Base Balance).

The Glutamate Dehydrogenase Reaction




The reaction catalyzed by glutamate dehydrogenase is:

The glutamine synthetase reaction is also important in several respects. First it produces glutamine, one of the 20 major amino acids. Second, in animals, glutamine is the major amino acid found in the circulatory system. Its role there is to carry ammonia to and from various tissues but principally from peripheral tissues to the kidney, where the amide nitrogen is hydrolyzed by the enzyme glutaminase (reaction below); this process regenerates glutamate and free ammonium ion, which is excreted in the urine.

Note that, in this function, ammonia arising in peripheral tissue is carried in a non-ionizable form which has none of the neurotoxic or alkalosis-generating properties of free ammonia.
Liver contains both glutamine synthetase and glutaminase but the enzymes are localized in different cellular segments. This ensures that the liver is neither a net producer nor consumer of glutamine. The differences in cellular location of these two enzymes allows the liver to scavenge ammonia that has not been incorporated into urea. The enzymes of the urea cycle are located in the same cells as those that contain glutaminase. The result of the differential distribution of these two hepatic enzymes makes it possible to control ammonia incorporation into either urea or glutamine, the latter leads to excretion of ammonia by the kidney.

When acidosis occurs the body will divert more glutamine from the liver to the kidney. This allows for the conservation of bicarbonate ion since the incorporation of ammonia into urea requires bicarbonate (see below). When glutamine enters the kidney, glutaminase releases one mole of ammonia generating glutamate and then glutamate dehydrogenase releases another mole of ammonia generating α-KG. The ammonia will ionizes to ammonium ion (NH4+) which is excreted. The net effect is a reduction in the concentration of hydrogen ion, [H+], and thus an increase in the pH (see also Kidneys and Acid-Base Balance).

Kamis, 05 Februari 2009

POWERS OF THE MIND

POWERS OF THE MIND

All over the world there has been the belief in the supernatural through the ages. All of us have heard of extraordinary happenings, and many of us have had some personal experience of them. I would rather introduce the subject by telling you certain facts, which have come within my own experience. I once heard of a man who, if anyone went to him with questions in his mind, would answer them immediately; and I was also informed that he foretold events. I was curious, and went to see him with a few fr iends. We each had something in our minds to ask, and, to avoid mistakes, we wrote down our questions and put them in our pockets. As soon as the man saw one of us, he repeated our questions and gave answers to them. Then he wrote something on paper, whi ch he folded up, asked me to sign on the back, and said, 'Don't look at it; put it in your pocket, and keep it there till I ask for it again'. And so on to each of us. He next told us about some events that would happen to us in the future. Then he said, 'Now, think of a word or sentence, from any language you like.' I thought of a long sentence from Sanskrit, a language of which he was entirely ignorant. 'Now take out the paper from your pocket', he said. The Sanskrit sentence was written there! He had written it an hour before with the remark, 'In conformation of what I have written, this man will think of this sentence.' It was correct. Another of us who had been given a similar paper, which he had signed and placed in his pocket, was also asked to think of a sentence. He thought of a sentence in Arabic, which it was, still less possible for the man to know; it was some passage from the Koran. And my friend found this written down on the paper.

Another of us was physician. He thought of a sentence from a German medical book. It was written on his paper.

Several days later I went to this man again, thinking possibly I had been deluded somehow before. I took other friends, and on this occasion also he came out wonderfully triumphant.

Well, I saw many things like that. Going about India you find hundreds of similar things in different places. These are in every country. Even in this country you will find some such wonderful things. Of course there is a great deal of fraud, no doubt ; but then, whenever you see fraud, you have also to say that fraud is an imitation. There must be some truth somewhere that is being imitated; you cannot imitate anything. Imitation must be of something substantially true.

In very remote times in India, thousands of years ago, these facts used to happen even more than they do today. It seems to me that when a country becomes very thickly populated, psychical powers deteriorates. Given a vast country thinly inhabited, th ere will, perhaps, be more of psychical power there. These facts, the Hindus being analytically minded, took up and investigated. And they came to certain remarkable conclusions; that is, they made a science of it. They found out that all these, though e xtraordinary, are also natural; there is nothing supernatural. They are under laws just the same as any other physical phenomenon. It is not a freak of nature that a man is born with such powers. They can be systematically studied, practiced and acquired . This science they call the science of Raja-Yoga. There are thousands of people who cultivate the study of this science, and for the whole nation it has become a part of daily worship.

The conclusion they have reached is that all these extraordinary powers are in the mind of man. This mind is a part of the universal mind. Each mind is connected with every other mind. And each mind, whenever it is located, is in actual communication with the whole world.

Have you ever noticed the phenomenon that is called thought-transference? A man here is thinking something, and that thought is manifested in somebody else, in some other place. With preparations- not by chance- a man wants to send a thought to anothe r mind at a distance, and this other mind knows that a thought is coming, and he receives it exactly as it is sent out. Distance makes no difference. The thought goes and reaches the other man, and he understands it. If your mind were an isolated somethi ng here, and my mind were an isolated something their, and there were no connection between the two, how would it be possible for my thought to reach you? In the ordinary cases, it is not my thought that is reaching you direct; but my thought has got to be dissolved into ethereal vibrations and those ethereal vibrations go into your brain, and they have to be resolved again into your brain, and they have to be resolved again into your own thoughts. Here is dissolution of thought, and there is a resoluti on of thought. It is a roundabout process. But in telepathy, there is no such thing; it is direct.

This shows that there is a continuity of mind, as the Yogis call it. The mind is universal. Your mind, my mind, all these little minds, are fragments of that universal mind, little waves in the ocean; and on account of this continuity, we can convey o ur thoughts directly to one another.

You see what is happening all around us. The world is one of influence. Part of our energy is used up in the preservation of our own bodies. Beyond that, every particle of our energy is day and night being used in influencing others. Our bodies, our v irtues, our intellect, and our spirituality, all these are continuously influencing others; and so, conversely, we are influenced by them. This is going on all around us. Now, to take a concrete example. A man comes; you know he is very learned, his lang uage is beautiful, and he speaks to you by the hour; but he does not make any impression. Another man comes, and he speaks a few words, not well arranged, ungrammatical perhaps; all the same, he makes an immense impression. Many of you have seen that. So it is evident that words alone cannot always produce an impression. Words, even thoughts, contribute only one-third of the influence in making an impression, the man, two-thirds. What you call the personal magnetism of the man- that is what goes out and impresses you.

In our families there are the heads; some of them are successful, others are not. Why? We complain of others in our failure. The moment I am unsuccessful, I say, so-and-so is the cause of the failure. In failures, one does not like to confess one's ow n faults and weaknesses. Each person tries to hold himself faultless and lay the blame upon somebody or something else or even on bad luck. When heads of families fail, they should ask themselves, why it is that some persons manage a family so well and o thers do not. Then you will find that the difference is owing to the man- his presence, his personality.

Coming to great leaders of mankind, we always find that it was the personality of the man that counted. Now, take all the great authors of the past, the great thinkers. Really speaking, how many thoughts have they thought? Take all the writings that h ave been left to us by the past leaders of mankind; take each one of their books and appraise them. The real thoughts, new and genuine, that have been thought in this world up to this time, amount to only a handful. Read in their books the thoughts they have left to us. The authors do not appear to be giants to us, and yet we know that they were great giants in their days. What made them so? Not simply the thoughts they thought, neither the books they wrote, nor the speeches they made, it was something else that is now gone, that is their personality. As I have already remarked, the personality of the man is two-thirds, and his intellect, his words, are but one-third. It is the real man, the personality of the man that runs through us. Our actions are but effects. Actions must come when the man is there; the effect is bound to follow the cause.

The ideal of all education, all training, should be this man-making. But, instead of that, we are always trying to polish up the outside. What use to polish up the outside when there is no inside? The end and aim of all training is to make the man gro w. The man who influences, who throws his magic, as it were, upon his fellow-beings, is a dynamo of power, and when that man is ready, he can do anything and everything he likes; that personality put upon anything will make it work.

Now, we see that though this is a fact, no physical laws that we know of will explain it by chemical and physical knowledge? How much of oxygen, hydrogen, carbon, how many molecules in different positions, and how many cells, etc., etc., can explain t his mysterious personality? And we still see, it is a fact, and not only that, it is the real man; and it is that man that lives and moves his fellow-beings, and passes out, and his intellect and books and works are but traces left behind. Think of this. Compare the great teachers of religion with the great philosophers. The philosophers scarcely influenced anybody's inner man, and yet they wrote most marvelous books. The religious teachers, on the other hand, moved countries in their lifetime. The diff erence was made by personality. In the philosopher, it is a faint personality that influences; in the great prophets it is temendous. In the former we touch the intellect, in the latter we touch life. In the one case, it is simply a chemical process, put ting certain chemical ingredients together, which may gradually, combine and under proper circumstances bring out a flash of light or may fail. In the other, it is like a torch that goes round quickly, lighting others.

The science of Yoga claims that it has discovered the laws, which develop this personality, and by proper attention to those laws and methods, each one can grow and strengthen his personality. This is one of the great practical things and this is the secret of all education.

Jumat, 30 Januari 2009

Types of pumps

Types of pumps

1- Displacement pumps:
Reciprocating
Screw pump
Gears pump
2- Axial flow pumps
3- Centrafugal pumps:
Pump Classification According to Purpose and Principle of Operation

(A) PUMP CLASSIFICATION ACCORDING TO PURPOSE
In accordance with their purpose, shipboard pumps can be di¬vided into three groups:
1. General service pumps whose function is to ensure the sea¬worthiness of the ship and to provide for the domestic needs of the
•crew and passengers, and also to maintain the necessary sanitary conditions on board.
2. Pumps of the shipboard systems, designed to serve the main
•and auxiliary systems, and to facilitate the maintenance of normal conditions for their operation.
3. Special-purpose pumps in tankers, trawlers, ice-breakers, life-saving ships and dredgers. General service pumps include:
(1) bilge pumps,
(2) sanitary pumps,
(3) fire pumps,
(4) emergency pumps.

(B) PUMP CLASSIFICATION ACCORDING TO PRINCIPLE OF OPERATION
The following types are distinguished:
1. Static head, or potential energy, pumps,
2. Dynamic head, or kinetic energy, pumps.
The first group of pumps, which mainly create a static head or potential energy, are of the positive displacement type and in¬clude reciprocating and rotary pumps.
In addition to the static head, the pumps of the second group impart considerable dynamic head, or kinetic energy, to the liquid being handled. The part of the kinetic energy (dynamic head) re¬quired to deliver the liquid to its destination is transformed into potential energy (static head) in special parts of the pump designed for this purpose. In other words, velocity head is converted into pressure head.
The second group includes centrifugal, propeller and jet pumps.

Rabu, 28 Januari 2009

FOOD HABBITS

FOOD HABBITS

food habits too follows various trends. There are times when Fast food are a craze and at times ppl suddenly turn health cautious eating only what is “green”. Trends in food are very common. Fast food sells like anything. It is a western concept that has gained large popularity in INDIA. Though largely disadvantageous ppl tend to neglect the health hazards caused by them…. Processed food are a little different from fast food. They are better than fast food but have some shortcomings too. They r not fresh, not homemade and above all not always a safe option..

Apart from the food habits the focus should also be on what is called “THE RICH MANS STUFF”. Charas , Ganja etc and other sedatives supplemented by less harmful cigrettes hooka etc are turning out to be a gr8 hit .

Then there are synthetically produced food stuffs that are forming the trend of the future. Tofu , spirulina etc The details of these trends in food are as follows

JUNK FOOD
The message is: avoid high calorie and carbohydrate-rich food, including junk foods and beverages, right from childhood, because the seed of obesity in adults is sown in early childhood. The oft-repeated medical advice may sound staid, but studies conducted by doctors of the All-India Medical Institute (AIIMS), have shown that obesity, if not checked in early childhood, leads to cardiovascular diseases, diabetes mellitus, insulin resistance, gall stone disease and reproductive disorders.
We think Indian fast food is a healthier option than the reviled burger or pizza. But now studies prove they are no better.

Doctors say change in the dietary habits of children and their survival on aerated drinks, chips, noodles, sweets and chocolates alone have led to poor oral health, obesity, calcium and vitamin D deficiency and many other problems amongst these children.

We are seeing an alarmingly high number of children having symptoms of pre-diabetes, which makes them more prone to diabetes when they grow up. Mostly these children are obese, feeding on high calorie junk food like chocolates, pizzas with low nutritional value. Physical exercise is negligible due to mounting pressure, making things worse. The need of the hour is to distract the youth from fast food as the trends of diseases and side effects of fast food are alarming..

FOOD TRENDS/PROCESSED FOODS
The Indian snack food market comprising bakery products, ready to eat mixes,instant food mixes, curries, chips, namkeens and other processed foods is large, diverse and dominated by the unorganized sector.
The popular milk products are cheese, butter, ghee, dairy whiteners and ice-creams.
What does the average middle class Indian eat in a day?
Chhole kulche, chana bhatura, samosa, kachori. Our own foods are killers. We don’t need the West to damage us. We are doing a good job of it ourselves

Recent reports on the dangers of trans-fatty acids in packaged foods.
We have to take these dangers very seriously.
Younger and younger people are today suffering from obesity and diabetes — thanks in part to such foods — which in turn is leading to cardio-vascular diseases.
Many high-end hospitals and posh schools offer/sell unhealthy and junk food. This is a case of commercialism triumphing over promotion of good health.
Young people are drawn towards eating these foods which are so attractively advertised on television...

The idiot box could not only be battering your senses day in and day out, but also affecting your eating habits.
Apart from changing the way people relate with one another, the obsession with prime time television is also impacting their culinary and dietary habits

Prime time is the time when maximum TV-viewing occurs, which also happens to be the time when most individuals are at home and winding up their daily grind.
They need to eat, relax and chat with the family prior to ending the day, but all this takes a back seat to TV.
Prime time television is forcing people to sacrifice meal planning and a balanced diet.
For housewives who feel TV is their only source of relaxation, regulate their time-table to suit television programmes .They either change their dinner time or eat before the TV set, which results in snacking on high calorie food. Families end up ordering out to minimise complex dinners being made at home


Youth and kids are influenced by commercials to crave convenience foods which imply that home food like roti and sabzi is boring.

Convenience foods like ready-to-eat packaged foods are high in sodium and preservatives and this can lead to disorders like hypertension, obesity, cardiovascular diseases and cancer.

Today's lifestyle has resulted in many changes in eating habits, and a move towards greater convenience. People are eating more processed and packaged food than before.
Whether in the form of munchies or biscuits, sauces or ready-to-eat foods, there are issues the consumer should consider before putting items into his shopping cart.
Most people don't check the labels of any of the packaged foods they buy. The reason being, anything that looks relatively fresh and is reasonably priced is considered good.

Minggu, 18 Januari 2009

Confectionery

Confectionery

Confectionery, processed food based on a sweetener, which may be sugar or honey, to which are added other ingredients such as flavourings and spices, nuts, fruits, fats and oils, gelatin, emulsifiers, colourings, eggs, milk products, and chocolate or cocoa. Confectionery, usually called sweets in Great Britain, or candy in the United States, can be divided into two kinds according to the preparation involved and based on the fact that sugar, when boiled, goes through different stages from soft to hard in the crystallization process. Typical of soft, or crystalline, sweets—smooth, creamy, and easily chewed—are fondants (the basis of chocolate creams) and fudge; typical hard, noncrystalline sweets are toffees and caramels. Other popular confections include nougats, marshmallows, the various forms of chocolate (bars or moulded pieces, sometimes filled), pastes and marzipan, candy floss (spun sugar, called barbe à papa in France and cotton candy in the United States), popcorn, liquorice, and chewing gum. The term also refers to flour confectionery, such as biscuits and pastries.

Records show that confectionery was used as an offering to the gods of ancient Egypt. Honey was used as the sweetener until the introduction of sugar into medieval Europe. Among the oldest types of confectionery are liquorice and ginger from East Asia and marzipan from Europe. Its production did not begin on a large scale until the early 19th century, when, with the development of special machinery, it became a British speciality. Today, annual world production of confectionery totals many millions of kilograms.

Jumat, 09 Januari 2009

Cane Sugar

Cane Sugar

Growing the Cane
Sugar cane is a sub-tropical and tropical crop that prefers lots of sun and lots of water - provided that its roots are not waterlogged. It typically takes about 12 months to reach maturity although the time varies widely around the world from as short as six months in Louisiana to 24 months in some places. Where it differs from many crops is that it re-grows from the roots so the plant lasts many cycles [or 'ratoons', a word derived from the Spanish to sprout] before it is worn out.

Harvesting
Sugar cane is harvested by chopping down the stems but leaving the roots so that it re-grows in time for the next crop. Harvest times tend to be during the dry season and the length of the harvest ranges from as little as 2 ½ months up to 11 months. The cane is taken to the factory: often by truck or rail wagon but sometimes on a cart pulled by a bullock

Extraction
The first stage of processing is the extraction of the cane juice. In many factories the cane is crushed in a series of large roller mills: similar to a mangle [wringer] which was used to squeeze the water out of clean washing a century ago. The sweet juice comes gushing out and the cane fibre is carried away for use in the boilers. In other factories a diffuser is used as is described for beet sugar manufacture. Either way the juice is pretty dirty: the soil from the fields, some small fibres and the green extracts from the plant are all mixed in with the sugar.

Evaporation
The factory can clean up the juice quite easily with slaked lime (a relative of chalk) which settles out a lot of the dirt so that it can be sent back to the fields. Once this is done, the juice is thickened up into a syrup by boiling off the water using steam in a process called evaporation. Sometimes the syrup is cleaned up again but more often it just goes on to the crystal-making step without any more cleaning. The evaporation is undertaken in order to improve the energy efficiency of the factory

Boiling
The syrup is placed into a very large pan for boiling, the last stage. In the pan even more water is boiled off until conditions are right for sugar crystals to grow. You may have done something like this at school but probably not with sugar because it is difficult to get the crystals to grow well. In the factory the workers usually have to throw in some sugar dust to initiate crystal formation. Once the crystals have grown the resulting mixture of crystals and mother liquor is spun in centrifuges to separate the two, rather like washing is spin dried. The crystals are then given a final dry with hot air before being stored ready for despatch.

Storage

The final raw sugar forms a sticky brown mountain in the store and looks rather like the soft brown sugar found in domestic kitchens. It could be used like that but usually it gets dirty in storage and has a distinctive taste which most people don't want. That is why it is refined when it gets to the country where it will be used. Additionally, because one cannot get all the sugar out of the juice, there is a sweet by-product made: molasses. This is usually turned into a cattle food or is sent to a distillery where alcohol is made.